期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 387, 期 3, 页码 602-605出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2009.07.070
关键词
alpha-Synuclein; Mutation; Parkinson's disease; SNCA
alpha-Synuclein is the main Constituent of Lewy bodies in familial and sporadic cases of Parkinson's disease (PD). Autosomal dominant point Mutations, gene duplications or triplications in the alpha-synuclein (SNCA) gene cause hereditary forms of PD. One of the alpha-synuclein point mutations, Ala53Thr, is associated with increased oligomerization toxicity leading to familial early-onset PD in humans. The amino acid in position 53 in alpha-synuclein is an alanine in humans, great apes and Old World primates. However, this amino acid is a threonine in the alpha-synuclein of all other examined species, including New World monkeys. Here, we present DNA sequence analysis of SNCA and the deduced amino acid sequences of alpha-synuclein cloned from Various different species, ranging from fish to mammals, which are known for their long-living potential. In all these investigated species the 53Thr is found. We conclude that 53Thr is not a molecular adaptation for long-living animals to minimize the risk of developing PD. (C) 2009 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据