期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 381, 期 4, 页码 625-629出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2009.02.102
关键词
G-protein coupled receptors; Prostaglandin; Cyclooxygenase; Glioma; T-cell factor; Cysteine-rich protein 61; Mitogen activated protein kinase; MAPK kinase; beta-Catenin; Microglial cells
资金
- National Institutes of Health [EY11291]
- Allergan Inc
Prostaglandin-F-2 alpha (PGF(2 alpha)) is a product of the cyclooxygenase pathway and is a local signaling molecule that activates a G-protein coupled prostanoid receptor named FP. FP receptors can Stimulate T-cell factor (Tcf) transcriptional activation by stabilization of beta-catenin and can upregulate the expression of mRNA encoding cysteine-rich protein 61 (Cyr61), a secreted extracellular matrix protein that stimulates angiogenesis. We now show in both HEK cells and human microglial cells that the induction of Cyr61 protein expression by the human FIR receptor utilizes a novel mechanism involving the activation of Ras and Raf followed by a MEK/ERK independent activation of Tcf signaling. The Upregulation of Cyr61 in microglial cells may contribute to glioma tumorigenesis and could be a potential therapeutic target. (C) 2009 Elsevier Inc. All rights reserved.
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