期刊
JOURNAL OF BIOMEDICAL OPTICS
卷 6, 期 3, 页码 319-325出版社
SPIE-INT SOCIETY OPTICAL ENGINEERING
DOI: 10.1117/1.1385511
关键词
doxorubicin; LH-RH; two-photon laser scanning microfluorometry; TPLSMF; drug trafficking; multicolor imaging
In this study, we present a spectroscopic study of the entry pattern of a chemotherapeutic drug (AN-152) and its carrier hormone ([D-Lys(6)]LH-RH) into living cancer cells, with the help of our two-photon probes and a home-built localized microspectrofluorometer coupled with two photon laser scanning microscope (TPLSM). Due to the inherent localization ability of TPLSM, we were able to identify the drug and carrier location in different compartments of the cancer cells in vitro. The apparent doxorubicin-assisted nucleic accumulation of AN-152 suggests a possible nuclear action of the drug on cell proliferation. (C) 2001 Society of Photo-Optical Instrumentation Engineers.
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