期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 49, 期 1-2, 页码 189-198出版社
ELSEVIER
DOI: 10.1016/S0169-409X(01)00134-X
关键词
mitochondria; mitochondrial DNA; mitochondrial diseases; protein targeting; RNA transport; peptide transport; lipophilic cations
Mitochondrial function is central to a range of cell processes and mitochondrial dysfunction contributes to a number of human diseases. Consequently there is growing interest in delivering large molecules such as nucleic acids, proteins, enzyme mimetics, drugs and probes to mitochondria within cells. The reasons for doing this are to understand how mitochondria function in the cell and to develop therapies for diseases involving mitochondrial damage. Here we review the methods that have been used to target large molecules to mitochondria and discuss some approaches under development. (C) 2001 Elsevier Science B.V. All rights reserved.
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