期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 117, 期 1-2, 页码 125-132出版社
ELSEVIER
DOI: 10.1016/S0165-5728(01)00328-9
关键词
neuropeptide Y (NPY); leukocyte subpopulations; NK-cells; CD5(+) CD11b(+) B-1 cells; activated monocytes; rats
Sympathetic nervous system activation mobilizes leukocytes but it is unknown whether the concomitant neuropeptide Y (NPY)-release also alters blood leukocyte counts. Using chronic intravenous (i.v.) cannulation of freely moving rats and flow cytometry, time-, dose- and subset-specific effects of NPY on blood leukocytes were investigated 1-15 min after injection: High-dose NPY increases leukocytes numbers by preferentially mobilizing CD4(+) T-cells, activated NKR-P1A(+) monocytes and NK-cells. Low-dose NPY significantly decreases B-lymphocyte and NK-cell numbers. Furthermore, NPY dose-dependently mobilizes a previously undetected IgM(low)CD5(+) CD11b(+) B-cell subpopulation in rats (B1-like B-lymphocytes). These data suggest a role for the sympathetic neurotransmitter NPY in neuroimmune alterations in vivo. (C) 2001 Elsevier Science B.V. All rights reserved.
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