Palladium-catalyzed allylic alkylation of tert-butyl(diphylmethylene)-glycinate with simple allyl esters under chiral phase transfer conditions

The first example of palladium-catalyzed allylic alkylation of,in imino ester with simple allyl esters in the presence of a chiral quaternary ammonium salt is reported. The presence of molecular sieves was found to have a beneficial effect on the enantioselectivity of the reaction by scavenging water from the system. Alkylated products vith e.e.s of up to 61% were obtained. (C) 2001 Elsevier Science Ltd. All rights reserved.