期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 423, 期 2-3, 页码 143-147出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-2999(01)01107-4
关键词
neurokinin A; tachykinin NK1 receptor; photoaffinity labeling; bioassay
资金
- NINDS NIH HHS [NS 31346] Funding Source: Medline
Neurokinin A (NKA) is a tachykinin peptide that binds with high affinity to the tachykinin NK, receptor. Recent homologous binding studies, however, have shown that neurokinin A is also a high-affinity ligand for the tachykinin NK, receptor. In this report, we demonstrate that a photoreactive neurokinin A analogue specifically labels the NK, receptor in rat submandibular gland membranes and show via bioassay that neurokinin A is a potent stimulator of salivary secretion. Through the use of specific non-peptide antagonists in both photolabeling and functional assays, we unequivocally demonstrate that neurokinin A can specifically interact with the NK, receptor in vivo and elicit NK, receptor-mediated physiological responses. (C) 2001 Published by Elsevier Science B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据