期刊
FEBS LETTERS
卷 501, 期 1, 页码 84-86出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(01)02631-X
关键词
genistein; alpha-glucosidase inhibitor; enzyme kinetics
Genistein is an isoflavone that is known to be contained in soybean. It was proved that genistein plays a pivotal role in homeostasis in the human body, In the course of screening for useful alpha -glucosidase inhibitors, we isolated and identified genistein as a candidate for alpha -glucosidase inhibitor from fermentation broths of a Strepromyces sp, Genistein was shown to be a reversible, slow-binding, non-competitive inhibitor of yeast alpha -glucosidase with a K-i value of 5.7 x 10(-8) M when the enzyme mixture was pretreated with genistein, These results show a possibility that genistein could be a useful tool for metabolic disorders. (C) 2001 Federation of European Biochemical Societies, Published by Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据