期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 66, 期 14, 页码 4803-4808出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo0100906
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Bioassay-guided fractionation of the extracts from the insect pathogenic fungus Cordyceps nipponica BCC 1389 led to the isolation of N-hydroxy- and N-methoxy-2-pyridones, cordypyridones A-D (1-4). Structures of these compounds, including absolute configuration, were determined by spectroscopic methods, chemical conversions and single-crystal X-ray diffraction analyses. Codypyridones A and B, atropisomers of each other, exhibited potent in vitro antimalarial activity with IC50 values of 0.066 and 0.037 mug/mL, respectively, while their cytotoxicity was much weaker.
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