期刊
DEVELOPMENTAL BIOLOGY
卷 235, 期 2, 页码 378-387出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/dbio.2001.0307
关键词
casein kinase I; morphogenesis; planar cell polarity; JNK; dishevelled; Wnt
资金
- NICHD NIH HHS [R01-HD36001-01A1, F32 HD08609-01] Funding Source: Medline
Wnt signals play important roles in development and oncogenesis and are transduced through at least two pathways: a canonical beta -catenin-dependent and a beta -catenin-independent cascade. Casein kinase I(CKI) is required in both invertebrates and vertebrates to transduce canonical Wnt signals. However, its role in the beta -catenin-independent pathway was unknown. During vertebrate embryogenesis, the beta -catenin-independent cascade is thought to control cell movements and has been postulated to be analogous to the Drosophila planar cell polarity pathway, which signals through the JNK cascade. Here, we report that blocking CKI function inhibits embryonic morphogenesis and activates JNK in cell lines. These studies suggest that CKI might also act in the beta -catenin-independent pathway and indicate a role for CKI during convergence extension in early vertebrate development. (C) 2001 Academic Press.
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