期刊
BLOOD
卷 98, 期 2, 页码 489-491出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood.V98.2.489
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- NCI NIH HHS [CA68496, CA18029, CA18221] Funding Source: Medline
- NIAID NIH HHS [AI46108] Funding Source: Medline
In 93 allograft recipients, the numbers of marrow B-cell precursors on days 80 and 365 correlated with the counts of circulating B cells, suggesting that the posttransplantation B-cell deficiency is at least in part due to insufficient B lymphopoiesis, Factors that could affect B lymphopoiesis were evaluated. The number of marrow B-cell precursors on days 30 and 80 was at least 4-fold lower in patients with grade 2 to 4 acute graft-versus-host disease (GVHD) compared with patients with grade 0 to 1 acute GVHD, The number of B-cell precursors on day 365 was 18-fold lower in patients with extensive chronic GVHD compared with patients with no or limited chronic GVHD. The number of B-cell precursors was not related to CD34 cell dose, type of transplant (marrow versus blood stem cells), donor age, or patient age. It was concluded that posttransplantation B-cell deficiency results in part from inhibition of B lymphopoiesis by GVHD and/or its treatment. (C) 2001 by The American Society of Hematology.
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