期刊
VACCINE
卷 19, 期 28-29, 页码 3834-3842出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(01)00135-9
关键词
rabies; human monoclonal antibodies; lyssaviruses
资金
- PHS HHS [NIDR-2-95-6R] Funding Source: Medline
Rabies immune globulin (RIG) is essential for post-exposure prophylaxis but is expensive and not widely available. Rabies virus-neutralizing human monoclonal antibodies (Mabs) were evaluated in vitro and in a Syrian hamster model as a potential future alternative. Seven Mabs neutralized representative rabies virus variants. However, a European bat lyssavirus was not neutralized by either Mabs or RIG. Moreover. Duvenhage virus was neutralized by RIG, but not by Mabs, and Lagos bat and Mokola viruses were neutralized by one Mab but not by RIG. In hamsters, one Mab resulted in protection that was comparable to human RIG. These results suggest that Mabs may provide a promising alternative to RIG. 2001 Published by Elsevier Science Ltd.
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