期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 98, 期 15, 页码 8732-8737出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.161126098
关键词
-
资金
- NCI NIH HHS [R37 CA038355, CA38355] Funding Source: Medline
- NHLBI NIH HHS [T32 HL007195, HL54729, HL07195, R01 HL054729] Funding Source: Medline
- NIAID NIH HHS [AI21487, AI46710, R01 AI046710, R01 AI045809, AI45809, AI41079] Funding Source: Medline
In T cell-deficient conditions, naive T cells undergo spontaneous homeostatic proliferation in response to contact with self-MHC/ peptide ligands. With the aid of an in vitro system, we show here that homeostatic proliferation is also cytokine-dependent. The cytokines IL-4, IL-7, and IL-15 enhanced homeostatic proliferation of naive T cells in vitro. Of these cytokines, only IL-7 was found to be critical; thus, naive T cells underwent homeostatic proliferation in IL-4(-) and IL-15(-) hosts but proliferated minimally in IL-7(-) hosts. In addition to homeostatic proliferation, the prolonged survival of naive T cells requires IL-7. Thus, naive T cells disappeared gradually over a 1-month period upon adoptive transfer into IL-7(-) hosts. These findings indicate that naive T cells depend on IL-7 for survival and homeostatic proliferation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据