期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 98, 期 15, 页码 8319-8325出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.111008398
关键词
-
资金
- NIGMS NIH HHS [R01 GM051753, T32 GM007122, T32 GM07122, R01 GM51753] Funding Source: Medline
Rearrangements between tandem sequence homologies of various lengths are a major source of genomic change and can be deleterious to the organism, These rearrangements can result in either deletion or duplication of genetic material flanked by direct sequence repeats. Molecular genetic analysis of repetitive sequence instability in Escherichia coli has provided several clues to the underlying mechanisms of these rearrangements, We present evidence for three mechanisms of RecA-independent sequence rearrangements: simple replication slippage, sister-chromosome exchange-associated slippage, and single-strand annealing. We discuss the constraints of these mechanisms and contrast their properties with RecA-dependent homologous recombination. Replication plays a critical role in the two slipped misalignment mechanisms, and difficulties in replication appear to trigger rearrangements via all these mechanisms.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据