期刊
NEUROREPORT
卷 12, 期 10, 页码 2255-2258出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200107200-00042
关键词
calcium influx; glutamate release; lamotrigine; synaptosomes
Lamotrigine (LAG) is an antiepileptic drug which is believed to suppress seizures by inhibiting the release of excitatory neurotransmitters. The present study was aimed at investigating the effect of LAG on the 4-aminopyridine (4AP)-evoked glutamate release in cerebrocortical nerve terminals (synaptosomes). LAG inhibited the release of glutamate evoked by 4AP in a concentration-dependent manner. This inhibitory effect was associated with a reduction in the depolarization-evoked increase in the cytoplasmic free Ca(2+) concentration ([Ca(2+)]c).
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