期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 310, 期 4, 页码 735-753出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1006/jmbi.2001.4807
关键词
ribosomal RNA structure; comparative sequence analysis; A : A and A : G base-pairs (non-canonical pairs); structure motifs; computational biology/bioinformatics (coaxial stacking)
资金
- NIGMS NIH HHS [GM48207, R01 GM048207-08, GM56544] Funding Source: Medline
This study reveals that AA and AG oppositions occur frequently at the ends of helices in RNA crystal and NMR structures in the PDB database and in the 16 S and 23 S rRNA comparative structure models, with the G usually 3 ' to the helix for the AG oppositions. In addition, these oppositions are frequently base-paired and usually in the sheared conformation, although other conformations are present in NMR and crystal structures. These A:A and A:G base-pairs are present in a variety of structural environments, including GNRA tetraloops, E and E-like loops, interfaced between two helices that are coaxially stacked, tandem G:A base-pairs, U-turns, and adenosine platforms. Finally, given structural studies that reveal conformational rearrangements occurring in regions of the RNA with AA and AG oppositions at the ends of helices, we suggest that these conformationally unique helix extensions might be associated with functionally important structural rearrangements. (C) 2001 Academic Press.
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