期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 310, 期 5, 页码 1167-1176出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1006/jmbi.2001.4816
关键词
MAGE-A4-derived peptides; cancer immunotherapy; tumour-associated antigen; MHC class I; HLA-A*0201
The heterotrimeric complex of the human major histocompatibity complex (MHC) molecule HLA-A*0201, beta (2)-microglobulin and the decameric peptide GVYDGREHTV derived from the melanoma antigen (MAGE-A4 protein has been determined by X-ray crystallography at 1.4 Angstrom resolution. MAGE-A4 belongs to a family of genes that are specifically expressed in a variety of tumours. MAGE-A4-derived peptides are presented by MHC molecules at the cell surface to cytotoxic T-lymphocytes. As the HLA-A*0201:MAGE-A4 complex occurs only on tumour cells, it is considered to be an appropriate target for immunotherapy. The structure presented here reveals potential epitopes specific to the complex and indicates which peptide residues could be recognised by T-cell receptors. In addition, as the structure could be refined anisotropically, it was possible to describe the movements of the bound peptide in more detail. (C) 2001 Academic Press.
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