期刊
JOURNAL OF HEART AND LUNG TRANSPLANTATION
卷 20, 期 8, 页码 897-900出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S1053-2498(01)00272-8
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We developed a limited sampling strategy (LSS) for predicting cyclosporine (Neoral) area under the curve from concentration-time data obtained specifically from lung transplant recipients. The optimal and most clinically convenient LSS for lung transplant recipients, based on patient wait time, number of blood samples required, percent prediction error, and assessment of predictive performance is one that requires 2 blood samples collected at 1 and 3 hours post-dose: AUC = 1.75 x C-1 + 4.91 x C-3 + 185.62.
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