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Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate
Xiaoqing Gan et al.
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Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition
Wen-I Wu et al.
PLOS ONE (2010)
Phosphoinositide (3,4,5)-Triphosphate Binding to Phosphoinositide-Dependent Kinase 1 Regulates a Protein Kinase B/Akt Signaling Threshold That Dictates T-Cell Migration, Not Proliferation
Caryll Waugh et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance
Jose R. Bayascas et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
PKBα/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival
Lana Bozulic et al.
MOLECULAR CELL (2008)
Spatial and temporal regulation of focal adhesion kinase activity in living cells
Xinming Cai et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Live-cell molecular analysis of Akt activation reveals roles for activation loop phosphorylation
Bharath Ananthanarayanan et al.
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AKT/PKB signaling: Navigating downstream
Brendan D. Manning et al.
CELL (2007)
Structural basis for the autoinhibition of focal adhesion kinase
Daniel Lietha et al.
CELL (2007)
Physiological roles of PKB/Akt isoforms in development and disease
B. Dummler et al.
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Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo
Veronique Calleja et al.
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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα but not S6K1
David A. Guertin et al.
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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
Estela Jacinto et al.
CELL (2006)
Evaluation of approaches to generation of tissue-specific knock-in mice
Jose R. Bayascas et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
mTOR•RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
RC Hresko et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter
MT Kunkel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)
Physiological functions of protein kinase B/Akt
ZZ Yang et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2004)
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase
JH Feng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries
JJJ Leahy et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change
CC Milburn et al.
BIOCHEMICAL JOURNAL (2003)
Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP
J Yang et al.
NATURE STRUCTURAL BIOLOGY (2002)
A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation
M Frödin et al.
EMBO JOURNAL (2002)
Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation
J Yang et al.
MOLECULAR CELL (2002)
The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB
RM Biondi et al.
EMBO JOURNAL (2001)
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