期刊
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
卷 26, 期 1, 页码 105-117出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.berh.2012.01.012
关键词
Sjogren's syndrome; Autoimmunity; Autoantibodies; Biological therapies; Neuropathy
类别
Sjogren's syndrome is a chronic autoimmune disease characterised by progressive injury to exocrine glands accompanied by diverse extra-glandular manifestations. The spectrum of Sjogren's manifestations expanded in recent years to include new symptoms and signs such as small fibre neuropathy, and also well-defined activity and prognostic indexes. Similar to other non-organ-specific autoimmune diseases, a mosaic of factors have been linked with the development and appearances of Sjogren's syndrome. Progress has been made unravelling those factors, including susceptibility genes, immunological parameters and various environmental factors in the last decade, some of which may enable targeted therapies, biological and non-biological ones, for patients suffering from this disease. Thus, herein we review the postulated aetiologies, pathogenesis and new insights related to Sjogren's syndrome. (C) 2012 Elsevier Ltd. All rights reserved.
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