期刊
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
卷 24, 期 1, 页码 15-26出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.berh.2009.08.006
关键词
ageing; osteoarthritis; elderly; cell senescence; oxidative stress; articular cartilage; menisci
类别
资金
- National Institute on Aging [RO1 AG16697, P30 AG021332]
- National Institute on Arthritis, Musculoskeletal and Skin Diseases [RO1 AR49003]
- American Federation for Aging Research
- Dorothy Rhyne Kimbrell and Willard Duke Kimbrell Professorship
Although older age is the greatest risk factor for osteoarthritis (OA), OA is not an inevitable consequence of growing old. Radiographic changes of OA, particularly osteophytes, are common ill the aged population, but symptoms of joint pain may be independent of radiographic severity in many older adults. Ageing changes in the musculoskeletal system increase the propensity to OA but the joints affected and the severity of disease are most closely related to other OA risk factors such as joint injury, obesity, genetics and anatomical factors that affect joint mechanics. The ageing changes in joint tissues that contribute to the development of CA include cell senescence that results in development of the senescent secretory phenotype and ageing changes in the matrix including formation of advanced glycation end-products that affect the mechanical properties of joint tissues. An improved mechanistic understanding of joint ageing will likely reveal new therapeutic targets to slow or halt disease progression. The ability to slow progression of OA ill older adults will have enormous public health implications given the ageing of our Population and the increase in other OA risk factors such as obesity. (C) 2009 Elsevier Ltd. All rights reserved.
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