期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 290, 期 28, 页码 17137-17144出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R115.636472
关键词
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资金
- National Institutes of Health [GM097348]
- Burroughs Wellcome Career Award
- University of Chicago Materials Research Science and Engineering Center (MRSEC) [DMR-1420709]
- Army Research Office sponsored Multidisciplinary University Research Initiative (ARO MURI) [W911NF-14-1-0403]
Cell physiological processes require the regulation and coordination of both mechanical and dynamical properties of the actin cytoskeleton. Here we review recent advances in understanding the mechanical properties and stability of actin filaments and how these properties are manifested at larger (network) length scales. We discuss how forces can influence local biochemical interactions, resulting in the formation of mechanically sensitive dynamic steady states. Understanding the regulation of such force-activated chemistries and dynamic steady states reflects an important challenge for future work that will provide valuable insights as to how the actin cytoskeleton engenders mechanoresponsiveness of living cells.
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