期刊
GENE THERAPY
卷 8, 期 15, 页码 1167-1173出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.gt.3301498
关键词
HGF; angiogenesis; stroke; gene therapy; delayed neuronal death
To develop a novel strategy to prevent delayed neuronal death (DND) following transient occlusion of arteries, the gene of hepatocyte growth factor (HGF), a novel neurotrophic factor, was transfected into the subarachnoid space of gerbils after transient forebrain ischemia. Importantly, transfection of HGF gene into the subarachnoid space prevented DND, accompanied by a significant increase in HGF in the cerebrospinal fluid. Prevention of DND by HGF is due to the inhibition of apoptosis through the blockade of bax translocation from the cytoplasm to the nucleus. HGF gene transfer into the subarachnoid space may provide a new therapeutic strategy for cerebrovascular disease.
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