期刊
GENE THERAPY
卷 8, 期 15, 页码 1142-1148出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.gt.3301509
关键词
gene delivery; adenovirus; replication-selective; E3 region; oncolytic; armed therapeutic virus
Successful therapies for cancer need to deal with the complexity associated with the human tumor. Studies of tumor and viral biology have progressed to a point where replicating viruses are now being engineered as potential treatments for human cancers. The complex nature of human cancers dictates that successful treatments will require combination therapies. To this end, we have focused on developing the gene delivery capacity of the replicating adenovirus, using the non-essential E3 region transcription unit as a target site for therapeutic transgene Insertions. Utilizing the endogenous expression machinery of the E3 region (promoter, splicing, polyA) we show that a therapeutic transgene, TNF, is efficiently expressed from the E3B region and with exclusive late gene expression kinetics. Potential clinical applications are discussed.
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