期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 6, 期 -, 页码 D1019-D1023出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/Horn
关键词
SWI/SNF; chromatin remodeling; bromodomain; review
资金
- NIGMS NIH HHS [5F32GM20229, GM49065] Funding Source: Medline
In eukaryotes, processes requiring access to DNA are inhibited by the structural packaging of the genome. A number of specialized ATP-dependent chromatin remodeling enzymes have evolved to overcome this inhibition. One subset of these enzymes, SWI/SNF, plays a critical role in the regulation of transcription, often functioning in concert with nuclear histone acetyltransferases (HATs). It remains unknown how these activities are coordinated. However, recent results revealing that the bromodomain, a motif common in these remodeling factors, constitutes an acetyl-lysine binding domain might provide insight into this process. Bromodomains may serve a role analogous to the signal transduction SH2 domain, by providing a means to recruit remodeling complexes to acetylated chromatin regions or to allosterically modify their function post-recruitment.
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