期刊
RADIOLOGY
卷 220, 期 2, 页码 373-380出版社
RADIOLOGICAL SOC NORTH AMER
DOI: 10.1148/radiology.220.2.r01au25373
关键词
carcinoid; fluorine, radioactive; gastrointestinal tract, CT; gastrointestinal tract, MR; gastrointestinal tract, neoplasms; gastrointestinal tract, PET; gastrointestinal tract, SPECT
PURPOSE: To evaluate fluorine 18 (F-18) dopa positron emission tomography (PET) in comparison with established imaging procedures in gastrointestinal carcinoid tumors. MATERIALS AND METHODS: After evaluation of the normal distribution of F-18 dopa, 17 patients with histologically confirmed tumors were examined with F-18 dopa PET. Results of 2-[fluorine 18]fluoro-2-deoxy-D-glucose (FDG) PET, somatostatin-receptor scintigraphy, and morphologic imaging (computed tomography and/or magnetic resonance imaging) were available for all patients. Results of the procedures were evaluated by two radiologists and two nuclear medicine specialists, whose consensus based on all available histologic, imaging, and follow-up findings was used as the reference standard. RESULTS: Ninety-two tumors were diagnosed: eight primary tumors, 47 lymph node metastases, and 37 organ metastases. F-18 dopa PET led to 60 true-positive findings (seven primary tumors, 41 lymph node metastases, 12 organ metastases); FDG PET, 27 (two primary tumors, 14 lymph node metastases, 11 organ metastases); somatostatin-receptor scintigraphy, 52 (four primary tumors, 27 lymph node metastases, 21 organ metastases); and morphologic imaging, 67 (two primary tumors, 29 lymph node metastases, 36 organ metastases). This resulted in the following overall sensitivities:F-18 dopa PET, 65% (60 of 92); FDG PET, 29% (27 of 92); somatostatin-receptor scintigraphy, 57% (52 of 92); morphologic procedures, 73% (67 of 92). Although the morphologic procedures were most sensitive for organ metastases, 18F dopa PET enabled best localization of primary tumors and lymph node staging. CONCLUSION:F-18 dopa PET is a promising procedure and useful supplement to morphologic methods in diagnostic imaging of gastrointestinal carcinoid tumors.
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