期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 12, 期 4, 页码 376-381出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0958-1669(00)00230-5
关键词
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The (beta alpha)(8)-barrel is a versatile single-domain protein fold that is adopted by a large number of enzymes. The (beta alpha)(8)-barrel fold has been used as a model to elucidate the structural basis of protein thermostability and in studies to interconvert catalytic activities or substrate specificities by rational design or directed evolution. Recently, the (beta alpha)(4)-half-barrel was identified as a possible structural subdomain.
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