期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 12, 期 4, 页码 295-303出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1006/scdb.2001.0257
关键词
suprachiasmatic nucleus; circadian rhythm; pacemaker; clock genes; retina
资金
- NIMH NIH HHS [MH63104] Funding Source: Medline
- NINDS NIH HHS [NS 34194, NS 38483] Funding Source: Medline
In mammals, a master circadian pacemaker driving daily rhythms in behavior and physiology resides in the suprachiasmatic nucleus (SCN). The SCN contains multiple circadian oscillators that synchronize to environmental cycles and to each other in vivo. Rhythm production, an intracellular event, depends on more than right identified genes. The period of the rhythms within the SCN also depends upon intercellular communication. Many other tissues also retain the ability to generate near 24-h periodicities although their place in the organization of circadian timing is still unclear. This paper focuses on the tissue-, cellular- and molecular level events that generate and entrain circadian rhythms in behavior in mammals and emphasizes the apparent differences between the SCN and peripheral oscillators.
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