Prognosis of acute poststreptococcal glomerulonephritis (APSGN) is excellent in children, when adequately diagnosed

Background: Recently, the prognosis of acute poststreptococcal glomerulonephritis (APSGN) has been reported as improved, compared with the results of previous studies. In an attempt to clarify this, we analyzed the clinical course of patients with APSGN. Methods: A total of 220 children with acute nephritic syndrome were treated in the affiliated hospitals of our department, between January 1988 and December 1997. Among them, 138 children who were diagnosed with APSGN according to the presence of hematuria. transient hypocomplementemia and evidence of group A beta-hemolytic streptococcal infection, were studied, Results: Serum creatinine and blood urea nitrogen levels at onset were 0,5 +/- 0.2 mg/dL and 20 +/- 12 mg/dL, respectively. There were no patients with renal dysfunction (serum creatinine level greater than or equal to1.5 mg/dL), but one patient with nephrotic syndrome. Blood pressure was well controlled in all patients and there were no patients with persistent hypertension. Serum complement levels were normalized within 12 weeks (100%), hematuria disappeared within 4 years (100%) and proteinuria disappeared within 3 years (100%) from the onset. Conclusions: These data indicate that the prognosis of APSGN during childhood is excellent, when adequately diagnosed and treated.