期刊
INFECTION AND IMMUNITY
卷 69, 期 8, 页码 5157-5161出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.69.8.5157-5161.2001
关键词
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资金
- NIDDK NIH HHS [R37 DK027083, DK27083, R01 DK027083] Funding Source: Medline
Wild-type Legionella pneumophila grows in human macrophages within a replicative phagosome, avoiding lysosomal fusion, while nonreplicative mutants are killed in lysosomes. Wortmannin, a phosphatidylinositol 3-kinase (PI3K) inhibitor, blocks phagocytosis of an avirulent mutant, but not of wild-type L. pneumophila, without affecting membrane ruffling and actin polymerization. These results show that wild-type and mutant Legionella strains use different entry pathways. They suggest that PI3Ks are involved in phagocytosis of an avirulent L. pneumophila mutant and regulate the ability of microorganisms to generate a replicative phagosome.
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