期刊
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY
卷 27, 期 1, 页码 25-38出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.bpg.2013.03.001
关键词
Gastrointestinal tract/*microbiology; Mucins/polysaccharides/glycans; Intestinal mucosa; Mucosal immunity; Microbial interactions/symbiosis; Akkermansia muciniphila; Bacteroides thetaiotaomicron; Inflammatory bowel diseases; Irritable bowel syndrome; Humans
资金
- ERC Advance Grant-MicrobesInside from the European Research Council [250172]
- Spinoza Award of the Netherlands Organization for Scientific Research (NWO)
- European Research Council (ERC) [250172] Funding Source: European Research Council (ERC)
The human gastrointestinal tract is colonised with a dense and diverse microbial community, that is an important player in human health and physiology. Close to the epithelial cells the mucosal microbiota is separated from the host with a thin lining of host derived glycans, including the cell surface glycocalyx and the extracellular secreted mucus. The mucosa-associated microbial composition differs from the luminal content and could be particularly important for nutrient exchange, communication with the host, development of the immune system, and resistance against invading pathogens. The mucosa-associated microbiota has adapted to the glycan rich environment by the production of mucus-degrading enzymes and mucus-binding extracellular proteins, and include mucus-degrading specialists such as Akkermansia muciniphila and Bacteroides thetaiotaomicron. This review is focussed on the host-microbe interactions within the glycan landscape at the epithelial interface and considers the spatial organisation and composition of the mucosa-associated microbiota in health and disease. (c) 2013 Elsevier Ltd. All rights reserved.
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