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Precancerous lesions in the stomach: From biology to clinical patient management

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ELSEVIER SCI LTD
DOI: 10.1016/j.bpg.2012.12.007

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Precancerous gastric lesions; Gastritis; Gastritis staging; Gastric cancer

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Gastric cancer is the final step in a multi-stage cascade triggered by long-standing inflammatory conditions (particularly Helicobacter pylori infection) resulting in atrophic gastritis and intestinal metaplasia: these lesions represent the cancerization field in which (intestinal-type) gastric cancer develops. Intraepithelial neoplasia is consistently recognized as the phenotypic bridge between atrophic/metaplastic lesions and invasive cancer. This paper addresses the epidemiology, pathology, molecular profiling, and clinical management of advanced precancerous gastric lesions. (C) 2013 Published by Elsevier Ltd.

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