期刊
JOURNAL OF NEUROVIROLOGY
卷 7, 期 4, 页码 307-310出版社
NATURE PUBLISHING GROUP
DOI: 10.1080/13550280152537157
关键词
central nervous system; drug therapy; JC virus; phenothiazines; progressive multifocal leukoencephalopathy
资金
- NCI NIH HHS [CA-71878] Funding Source: Medline
- NCRR NIH HHS [IP20RR15578] Funding Source: Medline
- NIAID NIH HHS [1P30AI42853] Funding Source: Medline
The human polyomavirus, JCV, is the etiologic agent of a fatal central nervous system (CNS) demyelinating disease known as progressive multifocal leukoencephalopathy (PML). PML occurs predominantly in immunosuppressed patients and remains an intractable complication in AIDS. To date, there are no effective therapies to treat PML. We previously demonstrated that the neuroleptic drug, chlorpromazine, inhibits the endocytic pathway used by JCV to infect glial cells. In this paper, we demonstrate that nontoxic doses of chlorpromazine are effective at inhibiting JCV multiplication and spread in a tissue culture model. The clinical efficacy of this drug or related compounds in treating PML has not been evaluated.
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