期刊
ANALYTICAL CHEMISTRY
卷 73, 期 15, 页码 3679-3686出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac010259f
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资金
- NCI NIH HHS [P01CA49210] Funding Source: Medline
- NCRR NIH HHS [P41RR00954] Funding Source: Medline
- NIGMS NIH HHS [R01 GM53825-05] Funding Source: Medline
Room-temperature ionic liquids are useful as solvents for organic synthesis, electrochemical studies, and separations. We wished to examine whether their high solubalizing power, negligible vapor pressure, and broad liquid temperature range are advantageous if they are used as matrixes for UV-MALDI. Several different ionic matrixes were synthesized and tested, using peptides, proteins, and poly(ethylene glycol) (PEG-2000). All ionic liquids tested have excellent solubilizing properties and vacuum stability compared to other commonly used liquid and solid matrixes. However, they varied widely in their ability to produce analyte gas-phase ions. Certain ionic matrixes, however, produce homogeneous solutions of greater vacuum stability, higher ion peak intensity, and equivalent or lower detection limits than currently used solid matrixes. Clearly, ionic liquids and their more amorphous solid analogues merit further investigation as MALDI matrixes.
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