期刊
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY
卷 25, 期 4-5, 页码 547-554出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.bpg.2011.08.001
关键词
Colorectal neoplasia; Docosahexaenoic acid; Eicosapentaenoic acid; Omega-3 polyunsaturated fatty acid; Prostaglandin
资金
- National Institute for Health Research
- Yorkshire Cancer Research
- SLA Pharma (UK)
- Medical Research Council [G116/146] Funding Source: researchfish
- MRC [G116/146] Funding Source: UKRI
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are naturally occurring omega (omega)-3 long-chain polyunsaturated fatty acids (PUFAs), which are found in highest quantities in oily fish such as sardines and mackerel. Epidemiological studies of the association between fish intake, omega-3 PUFA intake or blood omega-3 PUFA levels and colorectal cancer (CRC) risk have not consistently suggested beneficial effects of omega-3 PUFAs on CRC (and other gastrointestinal cancer) risk. However, dietary administration of one or both of the main omega-3 PUFAs in rodent models of colorectal carcinogenesis has been demonstrated to reduce colorectal tumour size and multiplicity, compatible with CRC chemopreventative activity. EPA has now been demonstrated to reduce rectal polyp number and size in patients with familial adenomatous polyposis. A randomized polyp prevention trial of EPA is underway in order to test chemopreventative efficacy against 'sporadic' colorectal neoplasia. (C) 2011 Elsevier Ltd. All rights reserved.
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