期刊
JOURNAL OF INFECTIOUS DISEASES
卷 184, 期 3, 页码 330-336出版社
UNIV CHICAGO PRESS
DOI: 10.1086/322037
关键词
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A point mutation in the promoter of the nitric oxide synthase 2 gene (NOS2), termed NOS2(Lambarene) (NOS2-G954C), protects heterozygous carriers against severe malaria as effectively as the sickle cell trait. In a prospective longitudinal study, 841 individual infections of initially 200 children (151 wild-type vs. 49 NOS2(Lambarene) carriers) were monitored for 4 years, to assess the rates of malarial attacks in the 2 groups; carriers of the NOS2(Lambarene) polymorphism were significantly less likely to experience malarial attacks than were others (P = .002). The distribution of the NOS2(Lambarene) polymorphism was investigated in malaria-endemic areas. It was found to be present with the highest frequency in Africa and at a lower frequency in Asia. Ex vivo studies showed that cells isolated from people with this polymorphism have a 7-fold higher baseline NOS activity, compared with the levels detected in cells from subjects with the wild-type gene (P = .003).
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