期刊
ANTIOXIDANTS & REDOX SIGNALING
卷 3, 期 4, 页码 565-575出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/15230860152542934
关键词
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A multiplicity of biological functions have been ascribed to nitric oxide (NO). It plays a significant role as a signal as well as a cytotoxic effector molecule. NO may, however, also play regulatory and/or modulatory roles in biology. A growing body of evidence suggests that posttranslational modifications of transcription factors serve a regulating role on gene transcription, particularly after changes of the redox state of the cell. Zinc fingers are the most prevalent transcription factor DNA-binding motif. As NO is able to S-nitrosate thiols of zinc-sulfur clusters leading to reversible disruption of zinc finger structures, this provides a molecular mechanism to regulate the transcription of genes. Current knowledge about effects of NO on the cellular zinc homeostasis and on the gene-regulating activity of zinc finger transcription factors is reviewed.
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