期刊
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY
卷 24, 期 5, 页码 635-646出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.bpg.2010.07.013
关键词
Liver fibrosis; Animal models; Human association studies
资金
- Deutsche Forschungsgemeinschaft [SFB TRR57]
- Aachen University (IZKF)
- Saarland University (HOMFOR)
Liver fibrosis is the sequel of chronic liver diseases and the main reason for increased mortality in affected patients The extent of liver fibrosis displays great interindividual variation even after controlling for exogenous factors Thus host genetic factors are considered to play an Important role in the process of liver scarring From a genetic perspective liver fibrosis is a complex trait with many genes contributing to the expression of the phenotype In genetically manipulated and Inbred animals several risk loci for liver fibrosis have been identified Some of these loci have been replicated in case-control studies of patients with hepatitis C infection In humans genetic risk loci were identified by single marker studies haplotype studies or the combination of single markers Recently the first genome-wide association studies have also been performed in patients with liver diseases Some of the identified gene variants have been functionally characterized in vitro thereby opening the potential for novel therapeutic approaches and risk stratification (C) 2010 Elsevier Ltd All rights reserved
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