期刊
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
卷 27, 期 1, 页码 63-68出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.beha.2014.04.001
关键词
acute promyelocytic leukemia; APL; extramedullary disease; CNS relapse
类别
In the last 2 decades an increasing number of patients reported with extramedullary involvement among relapsed acute promyelocytic leukemia (APL) patients. Several investigators related this phenomenon to the relatively new treatment of all-trans-retinoic-acid (ATRA). In this review article we will examine what has been reported in the medical literature on extramedullary disease in APL: the common sites to be involved, the clinical risk factors to its development, the role of ATRA and arsenic tri-oxide and the recommended treatment. (C) 2014 Elsevier Ltd. All rights reserved.
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