期刊
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
卷 23, 期 2, 页码 291-303出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.beha.2010.04.001
关键词
Human umbilical cord blood; mesenchymal and somatic stem cells; differentiation; regenerative potential
类别
资金
- Israeli Council for High Education (VATAT)
- Israel Ministry of Science and Technology
Regenerative medicine is the process of creating functional tissue with the aid of stem cells, to repair loss of organ function. Possible targets for regenerative medicine include orthopaedic, cardiac, hepatic, pancreatic and central nervous system (CNS) applications. Umbilical cord blood (CB) has established itself as a legitimate source for haematopoietic stem cell transplantation. It is also considered an accessible and less immunogenic source for mesenchymal, unrestricted somatic and for other stem cells with pluri/multipotent properties. The latter are capable of differentiating into a wide variety of cell types including bone, cartilage, cardiomyocytes and neural. They also possess protective abilities that may contribute to tissue repair even if in vitro differentiation is excluded. In view of the absence of treatment for many devastating diseases, the elucidation of non-haematopoietic applications for CB will facilitate the development of pioneering relevant cell therapy approaches. This review focusses on current studies using human CB-derived cells for regenerative medicine. (C) 2010 Elsevier Ltd. All rights reserved.
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