期刊
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
卷 21, 期 3, 页码 579-596出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.beha.2008.06.003
关键词
immune reconstition; cellular immunotherapy; allogene stem cell transplant; thymus
类别
资金
- Intramural NIH HHS [Z99 CA999999, Z01 BC010525-05] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [ZIABC010525, ZIABC010957] Funding Source: NIH RePORTER
Recovery of a fully functional immune system is a slow and often incomplete process following allogen stem cell transplantation. While innate immunity reconstitutes quickly, adaptive B and especially T-cell lymphopoeisis may be compromised for years following transplantation. Ina large part, these immune system deficits are due to the decrease of even absence of thymopoiesis following transplantation. Thereby, T-cell reconstitution initially relies upon expansion of mature donot Tcells a proliferation driven by high cytokine levels and the presence of allo reactive antigens. this peripheral mechanism of T-cell generation may have important clinical consequences. By expanding tumouricidal T cells it may provide a venue to enhance T-cellular immunotherapy following transplantation. Alternatively, decreased thymic function may impair long-term anti-tumour immunity and increase the likelihood of graft-versus-host diseases.
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