期刊
PEDIATRIC INFECTIOUS DISEASE JOURNAL
卷 20, 期 8, 页码 803-805出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00006454-200108000-00017
关键词
human immunodeficiency virus; nevirapine; pharmacokinetics; pregnancy; newborn
The safety, toxicity and pharmacokinetics of nevirapine were studied in HIV-infected pregnant women beginning chronic therapy late in the third trimester and in their infants. Initial dose pharmacokinetic profiles in the pregnant women were similar to those seen in nonpregnant adults. Serum nevirapine concentrations fell below the 100-ng/ml target concentration by Day 7 of life in four infants, suggesting that nevirapine elimination is accelerated in these infants compared with newborns whose mothers receive only a single intrapartum nevirapine dose.
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