期刊
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
卷 21, 期 4, 页码 667-675出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.beha.2008.06.005
关键词
reduced-intensity conditioning; hematopoietic cell transplantation; elderly; acute myeloid leukemia; cord blood
类别
资金
- NCI NIH HHS [P01 CA018029, P01 CA018029-36] Funding Source: Medline
Acute myeloid leukemia (AML) patients over the age of 55 years are generally more difficult to treat than younger patients due to intrinsic drug resistance and diminished tolerance to treatment. The unfortunate result is that conventional chemotherapy is toxic and rarely curative. Recent studies suggest a better outcome for older AML patients treated with reduced-intensity conditioning (RIC) hematopoietic cell transplantation (HCT) than those treated with conventional chemotherapy. However, there are major limitations to RIC HCT Some of these limitations may be able to be overcome, broadening the impact of allogeneic RIC HCT for older patients with AML Ways to improve RIC HCT include making more patients eligible for RIC HCT by improving initial complete response rates using novel agents or combinations; finding a way to more rapidly identify alternative stem cell sources, such as by using donors that have already undergone HLA profiling or by using unrelated cord blood; eliminating the requirement for a complete response prior to transplant; and educating patients and physicians about the chances of survival after RIC HCT when compared to conventional chemotherapy.
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