期刊
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
卷 28, 期 5, 页码 725-737出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.beem.2014.03.003
关键词
obesity; diabetes; nutrient partitioning; substrate utilization; hypothalamus; agouti-related peptide; neuropeptide Y; autonomic nervous system
资金
- CNRS
- Region Ile-de-France
- University Paris Diderot-Paris 7
- Societe Francophone du Diabete-Lilly
- Agence Nationale de la Recherche [ANR-09-BLAN-0267-02, ANR 11 BSV1 021 01]
- French Department of National Education and Research
- Societe Francophone du Diabete
- SFNEP-ANTADIR
- Centre National la Recherche Scientifique (CNRS)
- Societe Francophone du Diabete-Roche
The arcuate nucleus (ARC) of the hypothalamus is particularly regarded as a critical platform that integrates circulating signals of hunger and satiety reflecting energy stores and nutrient availability. Among ARC neurons, pro-opiomelanocortin (POMC) and agouti-related protein and neuropeptide Y (NPY/AgRP neurons) are considered as two opposing branches of the melanocortin signaling pathway. Integration of circulating signals of hunger and satiety results in the release of the melanocortin receptor ligand alpha-melanocyte-stimulating hormone (alpha MSH) by the POMC neurons system and decreases feeding and increases energy expenditure. The orexigenic/anabolic action of NPY/AgRP neurons is believed to rely essentially on their inhibitory input onto POMC neurons and second-orders targets. Recent updates in the field have casted a new light on the role of the ARC neurons in the coordinated regulation of peripheral organs involved in the control of nutrient storage, transformation and substrate utilization independent of food intake. (C) 2014 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据