期刊
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
卷 26, 期 6, 页码 759-770出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.beem.2012.05.001
关键词
deacetylase; energy homeostasis; metabolism; mitochondria; sirtuins
资金
- Academy of Finland
- Italian Association for Cancer Research
- Ecole Polytechnique Federale de Lausanne
- Faculty of Life Science
- EU [ERC-2008-AdG-23118]
- Velux Stiftung
- Swiss National Science Foundation [31003A-124713, 31003A-125487]
- Swiss National Science Foundation (SNF) [31003A_124713, 31003A_125487] Funding Source: Swiss National Science Foundation (SNF)
The maintenance of metabolic homeostasis requires the well-orchestrated network of several pathways of glucose, lipid and amino acid metabolism. Mitochondria integrate these pathways and serve not only as the prime site of cellular energy harvesting; but also as the producer of many key metabolic intermediates. The sirtuins are a family of NAD(+)-dependent enzymes, which have a crucial role in the cellular adaptation to metabolic stress. The mitochondria! sirtuins SIRT3, SIRT4 and SIRT5 together with the. nuclear SIRT1 regulate several aspects of mitochondrial physiology by controlling post-translational modifications of mitochondrial protein and transcription of mitochondrial genes. Here we discuss current knowledge how mitochondrial sirtuins and SIRT1 govera mitochondrial processes involved in different metabolic pathways. (C) 2012 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据