An efficient and fast procedure for the Hantzsch dihydropyridine synthesis under microwave conditions

A single-mode microwave cavity synthesizer with temperature and pressure control was used to accelerate the Hantzsch synthesis of 4-aryl and 4-alkyl-2.6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylates. In comparison with both conventional methods and microwave-assisted reactions performed in a domestic microwave oven. shorter reaction times and higher yields were obtained. The improved yields under microwave conditions made it possible to synthesize a small library. with acceptable purity.