Diagnosis/differential diagnosis of Cushing's syndrome: a review of best practice

Endogenous Cushing's syndrome is an uncommon endocrine disorder that can often prove challenging, for both initial diagnosis and subsequent differential diagnosis of the underlying cause. Understanding the advantages and pitfalls of the diagnostic methods used in Cushing's syndrome is essential for accurate diagnosis and differential diagnosis, and guidelines outlining the most appropriate approaches have recently been published. We examine how current practice guidelines can be used in a real case-based scenario, and review the recommended strategies to achieve successful diagnosis and differential diagnosis. (C) 2009 Elsevier Ltd. All rights reserved.