3.8 Article

Genioglossal inspiratory activation: central respiratory vs mechanoreceptive influences

期刊

RESPIRATION PHYSIOLOGY
卷 127, 期 1, 页码 23-38

出版社

ELSEVIER SCIENCE BV
DOI: 10.1016/S0034-5687(01)00230-4

关键词

control of breathing, central respiratory drive; mammals, humans; mechanics of breathing, upper airways; muscles, genioglossus; receptors, mechanoreceptors, upper airways; sleep, apnea; upper airways, dilator muscles

资金

  1. NCRR NIH HHS [M01 RR02635, M01 RR002635] Funding Source: Medline
  2. NHLBI NIH HHS [R01 HL048531, T32 HL007633, R01 HL48531, T32 HL07633, 1 P50 HL60292, P50 HL060292] Funding Source: Medline
  3. NIA NIH HHS [K23 AG024837] Funding Source: Medline

向作者/读者索取更多资源

Upper airway dilator muscles are phasically activated during respiration, We assessed the interaction between central respiratory drive and local (mechanoreceptive) influences upon genioglossal (GG) activity throughout inspiration. GG(EMG) and airway mechanics were measured in 16 awake subjects during baseline spontaneous breathing, increased central respiratory drive (inspiratory resistive loading, IRL). and decreased respiratory drive (hypocapnic negative pressure ventilation). both prior to and following dense upper airway topical anesthesia. Negative epiglottic pressure (P-epi) was significantly correlated with GG(EMG) across inspiration (i.e, within breaths). Both passive ventilation and IRL led to significant decreases in the sensitivity of the relationship between GG(EMG) and P-epi (slope GG(EMG) vs P-epi), but yielded no change in the relationship (correlation) between GG(EMG) and P-epi. During negative pressure ventilation, pharyngeal resistance increased modestly, but significantly. Anesthesia in all conditions led to decrements in phasic GG(EMG), increases in pharyngeal resistance. and decrease in the relationship between P-epi and GGEMG, We conclude that both central output to the GG and local reflex mediated activation are important in maintaining upper airway patency. (C) 2001 Elsevier Science B.V. All rights reserved.

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