期刊
JOURNAL OF VIROLOGY
卷 75, 期 16, 页码 7778-7784出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.75.16.7778-7784.2001
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类别
A Sindbis virus (SV) variant with a 6K gene partially deleted has been obtained. This SV De16K virus is defective in the proteolytic processing of virus glycoprotein precursor, transport of glycoproteins to the plasma membrane, and plaque phenotype. A revertant virus (SV Del6K-revQ21L) containing a point mutation in the deleted 6K gene was isolated and characterized. SV De16K-revQ21L has corrected the defects of proteolytic processing and transport of virus glycoproteins to the plasma membrane, but it still remains attenuated compared to wild-type (wt) SV, exhibiting defects in virus budding. Neither mutant nor revertant viruses are complemented by the coexpression in traits of a wt SV 6K gene.
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