期刊
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
卷 20, 期 8, 页码 419-434出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0165-9936(01)00078-4
关键词
LC-ES/MS/MS; pharmaceuticals; GC/MS water; wastewater; endocrine disruptors
Recently several methods have been developed for the determination of drugs and their metabolites in the lower ng/l range using solid phase extraction (SPE), derivatization, detection and confirmation by gas chromatography/mass spectrometry (GC/MS) and GC/MS/MS or LC-electrospray tandem MS (LC-ES/MS/MS). A wide range of pharmaceuticals from different medicinal classes can be determined down to the lower ng/l range. Due to the basically elevated polarity of pharmaceuticals either analysis by LC-ES/MS/MS or an efficient derivatization prior to measurements by GC/MS are mostly essential. A direct comparison of GC/MS and LC-ES/MS/MS displayed that only the latter allows for the analysis of the extreme polar betablockers atenolol and sotalol due to an incomplete derivatization of the functional groups. Further; the relative standard deviation using LC-ES/MS/MS was lower. However, when analyzing highly contaminated samples such as sewage a suppression of the electrospray ionization is likely to occur. Thus, to guarantee accurate and reproducible data either an efficient clean-up step has to be included into the sample preparation or an appropriate surrogate standard has to be spiked prior to SPE enrichment. (C) 2001 Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据